Revista argentina de cardiología
versión On-line ISSN 1850-3748
TARTAGLIONE, Jorge; GRAZIOLI, Gonzalo C.; SARMIENTO, Marcelo y GOLDSTRAJ, Leandro M.. Cardiovascular Events in a Closed Population: A 10-Year Follow-Up. Rev. argent. cardiol. [online]. 2008, vol.76, n.5, pp. 347-351. ISSN 1850-3748.
Background Previous epidemiological studies have reported that populations with similar risk factors had a different incidence and manifestation of cardiovascular diseases. Objectives To determine the incidence of MACE, composed by acute myocardial infarction, unstable angina, stroke, coronary angioplasty, coronary artery bypass graft surgery or cardiovascular death, as well as its association with risk factors in a closed population. Material and Methods We conducted a prospective cohort study on policemen during 1997. During the following ten years, those subjects who presented events were registered in a hospital database. Quantitative variables were analyzed with the t Student test and a logistic analysis was performed on qualitative variables. Results A total of 2,379 men were included. Mean age was 39.5±9.25 years. The prevalence of known risk factors was as follows: hypertension 11.1%; dyslipemia 20.3%; diabetes 2.4% and smoking habits 43.3%. Ninety percent of patients presented some type of MACE. The odds ratio were as follows: diabetes 4.54 (95% CI 2.1- 9.81), hypertension 2.3 (CI 95% 1.38-3.85), dyslipemia 2.74 (CI 95% 1.77-4.25) and smoking habits 1.48 (CI 95% 0.97- 2.28). A significant association was demonstrated with age, LDL cholesterol, fibrinogen serum levels and daily working hours. The area under the ROC curve of the Framingham score was 0.72 and for the European score was 0.71. Conclusion The importance of the classic coronary risk factors was similar to the one described by previous epidemiological studies; the relevance of fibrinogen, a non-classic risk factor, should be noted. Risk scores were regular predictors in this population. The special characteristic of the population analyzed enables the performance of the corresponding programs of prevention.
Palabras clave : Risk Factors; Disease Prevention; Cardiology; Prognosis.