Revista argentina de cardiología
versión On-line ISSN 1850-3748
TRAININI, Jorge C. et al. Myoblast Transplantation in the Heart: Outcomes at 5-year Follow-Up. Rev. argent. cardiol. [online]. 2008, vol.76, n.6, pp. 465-469. ISSN 1850-3748.
Several centers all around the world, including some institutions in Argentina, performed the first experiences in clinical phase with myoblast transplantation for cardiac regeneration. These initial studies were published during 2002 and 2003. The outcomes of these patients at 3-year followup were reported thereafter. It is in our interest to present the outcomes of the same group of patients 5 years after the implant. We have classified the compromised segments in 4 categories: transmural infarction, nontransmural infarction, ischemic and normal. In this way, 68 segments from 4 patients who were alive at 66±6.2 months were available for evaluation. There was a clear reduction in the number of segments with transmural infarction and an increase in the number of segments with nontransmural infarction and with ischemia. The number of segments with transmural compromise decreased from 15 to 3 (risk reduction of 80%; p=0.0005). Analysis of nontransmural segments should be performed in a comprehensive fashion. The global number of these segments increased from 7 to 9; however, preoperative nontransmural segments originally reported decreased from 7 to none. It might be considered that the global increase of these nontransmural segments corresponded to segments incorporated not only as a consequence of the progression of the disease but also at the expense of transmural segments, in a clear reduction of the fibrotic tissue.
Palabras clave : Myoblasts; Cells Transplantation; Heart Failure.