SciELO - Scientific Electronic Library Online

 
vol.77 número3Predictores de reperfusión miocárdica tisular luego de la angioplastia en el infarto agudo de miocardioUso de medicamentos en hipertensión arterial en el primer nivel de atención pública Argentina: La experiencia del Programa Remediar índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista argentina de cardiología

versión On-line ISSN 1850-3748

Resumen

ARRECHE, Noelia D. et al. Hemorrhagic Shock: Nitric Oxide in Anesthetized and Non Anesthetized Rats. Rev. argent. cardiol. [online]. 2009, vol.77, n.3, pp.181-186. ISSN 1850-3748.

Background We have previously demonstrated that hypovolemia induced by acute bleeding is accompanied by a dynamic, heterogenous and time-dependent activation of the cardiac nitric oxide synthase (NOS). This system might be involved in the hemodynamic anomalies observed after blood volume depletion. Objective To assess the role of the mitochondrial nitric oxide (NO) system in the adaptive response of the cardiovascular system in anesthetized and non anesthetized rats under hypovolemic shock. Material and Methods Animals were divided in four groups (n=7 animals per group): Group A, anesthetized control rats; group C, non anesthetized control rats; group AB, anesthetized rats subjected to bleeding (20% of blood volume), and group CB, non anesthetized rats subjected to bleeding. Oxygen consumption, functional activity of mitochondrial NOS (mtNOS) and mitochondrial production of NO were assessed. Results There were no significant differences in the values of respiratory parameters among the different study groups. Group AB had less functional activity of mtNOS compared to group A (12±2 and 19±1, respectively). This effect was even lower in non anesthetized animals subjected to bleeding (17±1 and 20±1, respectively). Mitochondrial production of NO decreased in anesthetized and non anesthetized animals with acute bleeding compared to controls. Conclusions Mitochondrial NO system might be involved in the adaptive response of the cardiovascular system under acute volume depletion, depending on the animal's degree of anesthesia.

Palabras clave : Hemorrhage; Mitochondria; Nitric Oxide; Hypotension.

        · resumen en Español     · texto en Español     · Español ( pdf ) | Inglés ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons