Abstract

MIGLIORE, Ricardo A. et al. Vascular and Valvular Load in Low-Flow/Low-Gradient Severe Aortic Stenosis and Normal Ejection Fraction. Rev. argent. cardiol. [online]. 2010, vol.78, n.1, pp.30-38. ISSN 1850-3748.

Background Some patients with aortic stenosis (AS) may present reduced stroke volume (SV) and low transvalvular gradients despite normal ejection fraction (EF). The reduction in the aortic valve area (AVA) and the increase in the vascular load contribute to decrease the SV. Objective To analyze the vascular and valvular load in low-flow/lowgradient severe aortic stenosis and normal ejection fraction. Material and Methods A total of 53 patients (70±12 years) with severe AS (AVA <1 cm²) and EF ≥50% were studied. Valvular load was estimated using the AVA and the energy loss index (ELI). Vascular load was evaluated by means of the effective arterial elastance (E_a) and systemic vascular resistance (SVR). Valvulo-arterial impedance (Z_va) was calculated as an estimation of global left ventricular (LV) afterload. E_a was estimated as the ratio between end-systolic pressure and SV. End-systolic pressure was obtained by tonometry. Z_va was calculated as: (systolic arterial pressure + mean net pressure gradient) / SV index. Patients were divided in two groups: normal flow (NF) (n=35), defined as a SV index >35 ml/m², or low flow (LF) (n=18), with a SV index ≤35 ml/m². Results Compared to NF patients, LF patients had lower AVA (0.59±0.18 versus 0.76±0.22 cm²; p<0.01), mean pressure gradient (28±5 versus 45±4 mm Hg; p<0.01) and ELI (0.35±0.13 versus 0.47±0.16 cm²/m²; p<0.01). Vascular load was greater in LF patients than in NF patients, with higher values of E_a (1.91±0.42 versus 1.24±0.33 mm Hg/ml; p<0.00001), SVR (2.119±506 versus 1.625 ± 443 mm Hg • min/L; p<0.001) and global afterload measured by Z_va (5.45±1.39 versus 3.95±1.10 mm Hg/ml/m²; p<0.001). At univariate analysis, SV correlated with E_a (r= -0.87, p<0.0001), SVR (r= -0.73, p<0.0001) and Z_va (r= -0.71, p<0.0001). E_a was the only independent predictor of reduced SV at multivariate analysis. Conclusions In patients with severe AS, the physiopathology of LF seems to be related to a significant increase in the vascular load.

Keywords : Aortic Stenosis; Arteries; Elasticity.

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