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Revista argentina de cardiología

On-line version ISSN 1850-3748

Abstract

MATORRA, Luis F. et al. Changes in Systolic and Diastolic Function in a Mouse Model Overexpressing Cardiac Angiotensin II AT-1 Receptor. Rev. argent. cardiol. [online]. 2013, vol.81, n.6, pp.473-479. ISSN 1850-3748.

Angiotensin II (Ang II) is involved in various patho-physiological processes through the activation of Ang II AT-1 receptors. The purpose of this study was to assess in vivo and in vitro systolic and diastolic ventricular function in mice overexpressing the cardiac-specific AT-1 receptor (AT1R). A second objective was to deter­mine whether acute and chronic ATIR blockade revert the changes in ventricular function. Mice were divided into four experimental groups. The first group included non-transgenic animals (NTG, n=10), the second group consisted of transgenic mice (TG, n=7) with cardiac-specific AT1R overexpression and the third and fourth groups were TG animals treated with losartan (L) for 7 (TG L7, n=9) and 30 days (TG L30, n=7), respectively. Transgenic animals exhibited left ventricular hypertrophy (LVH) which was only regressed with losartan treatment for 30 days. They also presented a significant decrease in shortening fraction from 47.1 ± 2.3% to 32.3 ± 1.3% (p max from 7073 ± 674 to 3897.5 ± 209.7 mm Hg/sec (p Isovolumic relaxation time and t1/2 were 24.1 ± 1.3 and 5.1 ± 0.5 ms, respectively, in the NTG group. These indexes increased to 33.1 ± 2.2 and 8.4 ± 0.4 ms, respectively, in TG mice (p In conclusion, cardiac-specific AT1R overexpression induces systolic and diastolic ventricular dysfunction which is completely reversed by AT1R blockade. This beneficial effect is independent of left ventricular mass changes.

Keywords : Angiotensin II; Ventricular Function; AT-1 Receptor.

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