Resumo

PAUZA, N L et al. Cutaneous signs as parameter in teratogenicity by heavy metal intoxication. Rev. argent. dermatol. [online]. 2007, vol.88, n.1, pp.28-37. ISSN 1851-300X.

Teratogenic effects of heavy metals (Cd^2+- and Pb^2+- acetates and Cu^2+- suphate) were studied on chick embryos, after the administration as a single dose. Test materials were injected into the yolk on day 12 of incubation. Tested concentrations were (nmole/g egg): Cd²⁺ Dose 1 (D1): 0.16 and Dose 2 (D2): 0.32; Pb²⁺: D1: 8.0 and D2: 16.0 and Cu²⁺: D1: 1.7 and D2: 3.3. Evaluations were performed after in ovo incubation for 12 and 60 hours. Embryonic mortality did not increase at the two dose levels of Cu²⁺ and Pb²⁺, while Cd²⁺ caused 30 and 86% of mortality, showing dose and time responses. Eggs treated with D2 of Cd²⁺ for 60 hs, significantly decreased the average of body mass embryo, when compared to the control group. Cd²⁺ administration was responsible for the most severe teratogenic signs compared to Cu²⁺ and Pb²⁺ treatments. It can be concluded that heavy metals are embryotoxic and teratogenics. We suggest that cutaneous and liver hemorrhages are the best signs to evaluate teratogenicity induced by Cd²⁺, Cu²⁺ and Pb²⁺.

Palavras-chave : Heavy metals; teratogenic effects; toxic effects; chick embryos; yolk sac membrane.

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