Abstract

WOLF, C.. Cutaneous hyperpigmentation and homeostasis of iron: role of the hepcidin. Rev. argent. dermatol. [online]. 2007, vol.88, n.2, pp.9-104. ISSN 1851-300X.

The cutaneous hyperpigmentation by melanin in zones of the skin exposed to the sun can be associated to an imbalance in the homeostasis of the iron. The hepcidin is a peptide responsible for the negative regulation of the absorption of the iron in the small intestine and of its liberation by the macrophages. It has, in addition, antimicrobial capacity. It is synthesized in the liver, secreted to the circulatory torrent and excreted by the urine. Its overexpression causes anemia and its deficit iron overload (accumulation in different organs and hereditary hemochromatosis), The antagonists of the hepcidin, could be used in the treatment of anemia resistant to erythropoyetin associated to chronic processes. On the other hand, the agonists or substances that stimulate the hepcidin production, could constitute a treatment in diseases with overload of iron (siderosis) and therefore, to correct the associate.hyperpigmentation.

Keywords : Hepcidina; Hiperpigmentación cutánea; Metabolismo del hierro; Anemias inflamatorias; Hemocromatosis.

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