Abstract

CARBO AMOROSO, E J et al. Tongue ulceration as a presentation of Histoplasma capsulatum infection. Rev. argent. dermatol. [online]. 2008, vol.89, n.2, pp.112-118. ISSN 1851-300X.

The progressive disseminated histoplasmosis is a disease produced by reactivation of latent infection in immunocompromised host, specially in persons with defective cell-mediated immunity. There are acute, subacute and chronic forms in the progressive illness. Focal lesions, specially mucocutaneous ulcers, are most frequent in the chronic disseminated forms. We reported a patient with rheumatoid arthritis treated with disease modifying antirheumatic drug (DMARD), with an ulcer of the tongue as only clinical manifestation of a chronic disseminated histoplasmosis. The histopathology was compatible, and the culture was positive for Histoplasma capsulatum. The serology for the HIV was negative. There are few published cases of this isolated form, particularly in patients with HIV negative serological test. Itraconazole and amphotericin B are the most frequently drugs used for the treatment in this disease. Clinical data on the new azoles, voriconazole and posaconazole, are limited.

Keywords : Tongue ulceration; Chronic disseminated histoplasmosis; Immunodepression; Histoplasma capsulatum.

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