Abstract

ELGUETA-NOY, A et al. Extended Bullous Erythema Multiforme Associated To Herpes Simplex Virus Infection. Rev. argent. dermatol. [online]. 2009, vol.90, n.4, pp.00-00. ISSN 1851-300X.

Erythema Multiforme (EM) is a generally benign and self-limited acute cutaneous reaction, associated with Herpes Simplex Virus (HSV) infection.  It is characterized by polymorphic "target" lesions in extremities and mucosal tissues.  We report a 22-year old patient with papules, vesicles and blisters, which evolved to cover 90% of the body in three weeks.  We performed a PCR study for HSV, which was positive in a crust.  A skin biopsy and positive immunohistochemical stain for LT CD4+ were compatible with bullous EM associated with HSV.  We underline the importance of pathological clinical correlation, reinforced by a virological study, in the diagnosis of this case with atypical symptoms. The laboratory findings confirmed literature descriptions with respect to the pathogenicity of EM associated with HSV.

Keywords : Erythema Multiforme; Bullous Erythema Multiforme; Herpes Simplex Virus.

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