Abstract

NIJAMIN, TR et al. Graft vs host disease after transfusion in a patient with acute linfoblastic leukemia. Rev. argent. dermatol. [online]. 2012, vol.93, n.4. ISSN 1851-300X.

Graft vs host disease (GVHD) is a process triggered by immune T cells, that react immunocompetent donor tissue against a recipient immunocompromised. This causes severe multiorgan damage in the receiving agent. Cutaneous manifestations are an important clinical sign in early periods. Postranfusional GVHD (GVHD-PT) is a rare entity with high mortality rate, observed in patients after transfusion with blood products not previously irradiated. Corticosteroids are the mainstay of treatment after installation of the box, however prevention with leukoreduction and irradiation of blood components remains the mainstay to prevent its development. We present a patient 5 years of age, diagnosed with acute lymphoblastic leukemia at high risk with a history of multiple transfusions of red blood cells without prior radiation treatment, who is performed dermatological and histopathological diagnosis posttransfusion acute GVHD.

Keywords : Postransfusion graft versus host disease; GVHD; Red blood cells transfusion.