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Revista argentina de dermatología

On-line version ISSN 1851-300X


RAMOS, L. Dress syndrome: A case report and a review. Rev. argent. dermatol. [online]. 2013, vol.94, n.3. ISSN 1851-300X.

DRESS syndrome is a severe hypersensitivity reaction to drugs, characterized by: rash, fever, lymphadenopathy, involvement of internal organs and blood disorders. In this work we present the case of a 30 years old man, with a history of seizures that had been receiving carbamazepine and presented during seven days confluent maculo-papular exanthema that spread to almost the entire body, accompanied by conjunctivitis, fever headache, and lymphadenopathy, these clinical parameters showed leucocytosis with atypical cells and alterations in liver function tests. The skin biopsy was consistent with the drug reaction that confirmed the diagnosis of DRESS syndrome. When the drug treatment was interrupted, the patient presented clinical and laboratory improvements, after corticosteroid administration. We describe the pathogenesis, diagnostic criteria, clinical features and therapeutics available today.

Keywords : DRESS syndrome; Drug hypersensitivity; Eosinophilia.

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