Abstract

PEREZ- ELIZONDO, AD  and  ACHENBACH, RE. Methotrexate stomatitis: A brief review. Rev. argent. dermatol. [online]. 2016, vol.97, n.4, pp.30-38. ISSN 1851-300X.

The use of methotrexate as immunomodulator and antimetabolite has been increasing because of its therapeutic effectiveness, low cost, and simple scheme single dose weekly. However, have recently been reported serious adverse effects related to administration, including stomatitis. Mouth ulcers are the most frequent oral adverse effect and relate to the lack of supplemental folic acid, iatrogenic errors caused by ingestion or drug interactions.

Keywords : methotrexate; oral ulceration; mucositis; drug-induced stomatitis.