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Revista argentina de dermatología

On-line version ISSN 1851-300X


LEROUX, MB; GOROSITO, M; BERGERO, A  and  PINEDA, IS. Scleromyxedema. Case report. Rev. argent. dermatol. [online]. 2020, vol.101, n.1, pp.121-130. ISSN 1851-300X.

A female patient presents with a generalized papular rash involving face, trunk, and four limbs. The skin is thickened and darkened, forming yellowish erythematous plaques that are linearly arranged papules. It is assumed as a generalized sclerodermiform syndrome and a comprehensive study and corresponding differential diagnosis is performed. The histopathological study of the skin showed an excessive increase of interstitial mucin, fibroblast activity and thickening of collagen bundles. The characteristic clinical expression and the histopathological study added to the extra cutaneous involvement lead to the diagnosis of scleromyxedema. There was no evidence of monoclonal gammopathy. Prednisone, thalidomide and hydroxychloroquine are indicated with excellent evolution.

Keywords : connective tissue disease; mucinoses; scleromyxedema; dermatoscopy.

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