Abstract

BELATTI, A et al. Successful treatment of acute lipodermatosclerosis with doxycycline: report of ten cases. Rev. argent. dermatol. [online]. 2020, vol.101, n.4, pp.81-90. ISSN 1851-300X.

Doxycycline, a second generation semi-synthetic tetracycline, widely used for the treatment of dermatological diseases for its antimicrobial effects, has shown in many clinical studies its actions as a powerful anti-inflammatory drug. Approved by the FDA as a complementary therapy in adult periodontitis, and of the papulopustular form of rosacea. In addition, other indications for inflammatory processes are described in the literature, such as calcinosis cutis, livedoid vasculitis, blistering pathologies, among others. We present a series of 10 patients with lipodermatosclerosis who presented an effective response to their pathology when receiving treatment with doxycycline for 3 months. Its therapeutic efficacy, accessibility and low association with adverse effects are highlighted.

Keywords : sclerosing panniculitis; tetracyclines; doxycycline; venous hypertension.