Revista argentina de endocrinología y metabolismo
On-line version ISSN 1851-3034
CHAILA, MZ et al. Prevalence of Metabolic Syndrome in Children and Adolescents by Different Diagnostic Criteria and their Correlation with Levels Leptin and Adiponectin. Rev. argent. endocrinol. metab. [online]. 2012, vol.49, n.3, pp. 103-114. ISSN 1851-3034.
The study aims were to detect subjects with obesity, overweight and components of Metabolic Syndrome (MS) in a child and adolescent populations. Also to determine the frequency of MS according to different criteria and compare them with Leptin and Adiponectin levels. 700 subjects between 6 and 19 years through standardized surveys, anthropometric and blood pressure measurements were studied. In those with 1 or more components of MS (n: 138-20 %), blood glucose, insulin, lipid profile, leptin and adiponectin were analyzed. MS were defined according criteria of Cook, or De Ferranti or Weiss. A descriptive statistical analysis showing the mean and 95 % confidence intervals (CI) were made. The association analysis was performed by t and chi-square tests with a significance level of 5 %. In the population studied by body mass index there were a 14 % of obesity and 22 % of overweight and through a waist circumference 15 % of obesity and 6 % of overweight. There was a strong association between overweight/obesity with hypertension and in a lesser degree, with other risk factors as HOMA index, HDL-cholesterol and triglycerides. The prevalence of MS according Cook was 15 %, according to De Ferranti 18 % and Weiss was 14 %. We speculate that the major percentage was obtained with the De Ferranti criteria, because the percentiles and cut-offs are more demanding. The mean value of leptin was significantly higher and the mean value of adiponectin was significantly lower in patients with MS according to the three criteria used (p < 0.01). It is necessary to establish a uniform standards and criteria to characterize MS in childhood and adolescence because there is no agreement on its definition, due to changes during growth and development that prevent the establishment of precise cut-off values. The authors do not have conflicts of interest.
Keywords : Obesity; Overweight; Metabolic syndrome; Leptin; Adiponectin.