Revista argentina de endocrinología y metabolismo
On-line version ISSN 1851-3034
ABREGU, AV et al. Elevated Soluble E-selectin levels in an Infant-juvenile Population with Overweight. Rev. argent. endocrinol. metab. [online]. 2012, vol.49, n.3, pp. 119-123. ISSN 1851-3034.
Childhood overweight is associated to overweight/obesity adulthood and it is a risk factor for diabetes and cardiovascular disease. Endothelial dysfunction is the initial stage of atherosclerosis and precedes earliest anatomical evidence thereof. This process is regulated by adhesión molecules located on the surface of leucocytes and endothelial cells and would have an important role in the prediction of cardiovascular events. Between these molecules, E-selectin (E-S) is a glycoprotein that is express exclusively on activated endothelial cells in response to inflammatory cytokines. It has suggested that increases of soluble form of E-S (sE-S) could be an specific marker of damaged vascular endhotelium. The aim of this study was determine plasma levels of sE-S in overweight children and its relationship with anthropometric and biochemical variables. Forty overweight children aged between 7 to 14 years, and 20 control children of similar age and sex, were studied. Inclusión criteria was a BMI ≥ 85th percentile and below 95th percentile, for age and sex. Waist circunference (WC), BMI, Tanner stage and blood pressure were determined. In both groups fasting blood glucose and insulin, fibrinogen (Fg), high sensitivity C-reactive protein (hsCRP), sE-S and lipid profile were analyzed. The data were analyzed with the SPSS 15.0 program for Windows, expressed as the median and interquartile range. The Spearman's coefficient were used to measure correlations between the studied variables. Overweight subjects presented higher levels of sE-S [72.0 (50.5-92.5) vs. 24.0 (18.5-5,0) ng/ml, p = 0.0001], hsCPR [1.9 (0.8-4.4) vs. 0.3 (0.2-1.1) mg/l, p = 0.001], Fg [350 (315-460) vs. 247 (235-265) mg/dl, p = 0.0001]. Also insulin and triglycerides values were elevated. sE-S was correlated positivily with WC (r = 0.40, p = 002), hs PCR (r = 0.58, p = 0.0001) and Fg (r = 0.50, p = 0.004). These results suggest the presence of endothelial activation and a proinflammatory state in the studied population, and highlight the importance of weight control in children to reduce cardiovascular risk in adulthood. The authors do not have conflicts of interest.
Keywords : E-selectin; Overweight; Inflammation; Atherosclerosis.