Revista argentina de endocrinología y metabolismo
On-line version ISSN 1851-3034
PISAREV, MA. Pathophysiology of Endocrine Exophthalmos. Rev. argent. endocrinol. metab. [online]. 2012, vol.49, n.3, pp. 134-137. ISSN 1851-3034.
The pathophysiology of endocrine exophthalmos has changed with the advances of Medicine. Described for the first time associated with hyperthyroidism by Graves and von Basedow, further studies demonstrated that it also may occur in patients with autoimmune thyroiditis. It is caused by the increase of retro ocular tissue volume. An exophthalmos producing substance (EPS) was found in the serum of those patients. The experimental demonstration that exophthalmos may be prduced by an autoimmune mechanism, and the finding that a circulating immunoglobulin, the Long Acting Thyroid Stimulator (LATS) is the cause of Graves disease, led to the present concept on the pathogrenesis of this disease The authors do not have conflicts of interest.
Keywords : Exophthalmos; Thyroid; Autoimmunity; Graves; Thyroid.