Revista argentina de endocrinología y metabolismo
On-line version ISSN 1851-3034
ASTARITA, G; GAUNA, A; GURFINKIEL, M and SEQUERA, A. Thyroid Autoimmunity: Common and Distinctive Pathogenic Mechanisms in Hashimoto's Thyroiditis and Graves' Disease. Rev. argent. endocrinol. metab. [online]. 2012, vol.49, n.3, pp. 138-144. ISSN 1851-3034.
Autoimmune thyroid disease (ATD) is the most common disorder that leads to thyroid gland dysfunction. ATD manifests in various clinical forms, such as Hashimoto's Thyroiditis (HT) and Graves' Disease (GD). The relation between HT and GD has been discussed for decades. Even if they greatly differ in their clinical features and treatment, some people believe they are the opposite sides of the same coin. In their pathogenesis, they share some mechanisms, such as genetic susceptibility, shown by the fact that they tend to occur both in the same person and within the same family. However, differences in the local micro-environment can determine the distinct phenotypic expression or the switch from one disease to the other. The aim of this monograph was to investigate similarities and differences between HT and GD at the diverse stages leading to the development of autoimmunity. No financial conflicts of interest exist.
Keywords : Hashimoto's thyroiditis; Graves' disease; Thyroid autoimmunity.