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Acta toxicológica argentina

On-line version ISSN 1851-3743


DIAZ, Mariano et al. Isoniazid seizures: A toxicological cause to consider. Acta toxicol. argent. [online]. 2015, vol.23, n.2, pp.79-82. ISSN 1851-3743.

Pediatricians do not usually considered isoniazid (INH) neurotoxicity in cases of patients with severe seizure disorders. INH is one of the most suitable drugs in the treatment and chemoprophylaxis of tuberculosis. It is usually indicated to the family group, due to the epidemiological characteristics of this disease, allowing a wide availability in homes and being able to cause accidental or intentional poisoning. An acute neurotoxic picture, expressed as a convulsive syndrome or coma, which does not improve with the usual treatments, characterized severe intoxication. A case of a patient with severe intoxication with isoniazid is presented. The extended anamnesis, along with an early diagnosis and the specific antidote treatment, set the fundamental basis for the favorable evolution of the patient.

Keywords : Intoxication; Isoniazid; Seizure; Metabolic acidosis.

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