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Acta toxicológica argentina

On-line version ISSN 1851-3743


SANCHEZ-INFANTE, Clara I. et al. A qualitative comparative analysis of signs and symptoms of heptachlor-based mixtures poisoning. Acta toxicol. argent. [online]. 2016, vol.24, n.1, pp.2-9. ISSN 1851-3743.

Chemical mixtures or the conjoint presence of signs and symptoms of chronic poisoning are two of the main challenges to the toxicologic and epidemiologic study of exposure to pesticides. In this study was explored the applicability of crispsets qualitative comparative analysis (csQCA) to overcome these diffculties. Data on symptoms and signs of poisoning from 43 agricultural workers living in Guamo or Espinal (Cundinamarca, Colombia) were collected, and the presence of heptachlor was measured in total blood with gas chromatography with electron capture detector. Truth tables with main confgurations were performed, and consistence and coverage were estimated. Heptachlor was detected among 90.70% of workers. Forty-nine symptoms and signs were reported, being the most frequent sleep disorders, dizziness and blurred vision. Five confgurations were associated with the detection of heptachlor in blood (coverage: 0.872 and consistence: 0.971), although only three are useful for clinical practice. This procedure allowed the design of a list of screening for detection of individuals with exposure to heptachlor. This experience showed one of the potential uses of csQCA in toxicology. Future studies may further explore the predictive value of these fndings in different populations.

Keywords : Organochlorine; Pesticide poisoning; Chronic exposure; Colombia.

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