Abstract

PAIXAO, Yasmim Dayane Leal et al. Comparative study with dry crude extracts of Ananas comosus L. Merril using LC₅₀ and erythrocyte osmotic fragility as toxicity parameters. Acta toxicol. argent. [online]. 2019, vol.27, n.1, pp.30-36. ISSN 1851-3743.

Ananas comosus, popularly known as pineapple, has well defined plant anatomy and numerous pharmacologically active phytochemicals. Some of these are responsible for the species antimicrobial potential, which has been widely studied given the bac­terial resistance to the currently used antibiotics. Considering this, it is defined that the main characteristic of a drug is the absence of toxic effects, thus, there is a need to seek data regarding the toxicity of A. comosus, collaborating for its possible use as a drug. Comparing hydroalcoholic extracts from the crown leaves, skin and pulp of the infructescence, it was possible to determine that the three tested extracts are non-toxic, being the one with the lowest toxicity to Artemia salina Leach (leaves extract with LC₅₀ equal to 994 μg/mL) and to lamb's blood (pulp extract with percentage of haemolysis equal to 0.83%). Studies concerning principles and methodologies similar to those used here have found comparable results stating the low toxicity of the plant. These results contribute to the research that promotes the use of pineapple as a phytotherapeutic agent and reaffirms its presence in the Brazilian Unified Health System.

Keywords : Ananas comosus; Fragilidad eritrocitaria; Artemia salina; Pineapple; Erythrocyte; LC₅₀.

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