Abstract

PEREZ-AMADOR, MC; MUNOZ OCOTERO, V  and  GARCIA JIMENEZ, F. Phototoxic compounds and biological activity of extracts from Eupatorium morifolium Mill. (Asteraceae). Phyton (B. Aires) [online]. 2008, vol.77, pp.21-29. ISSN 1851-5657.

Leaves of Eupatorium morifolium Mill. were analyzed for phototoxic compounds, and the toxicity of their hexane extract was evaluated against Bacillus subtilis. The phototoxic compounds were analyzed by TLC. In the plate, pale blue spots indicated the presence of these compounds. This was confirmed by the UV extract spectrum and the antibacterial activity against Bacillus subtilis. The biological activity of the leaf extracts (hexane, ethyl acetate or methanol) was also studied. The antiinflammatory activity was determined using the edema test on mouse ears, and the bactericide activity was assayed against Bacillus subtilis and Escherichia coli. A strong anti-inflammatory activity was shown by the leaf extracts. The ethyl acetate extract exhibited the strongest bactericide activity, followed by the methanol and hexane extracts.

Keywords : Asteraceae; Phototoxic compounds; Bactericide activity; 12-O-tetradecanoylphorbol-13-acetate (TPA).

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