Abstract

REYES GUZMAN, Edwin Alfredo; VEGA CASTRO, Nohora Angélica  and  REYES MONTANO, Edgar Antonio. Diseño de péptidos inhibidores de interacciones de la subunidad GluN2B del receptor NMDA en isquemia. Rev. cienc. tecnol. [online]. 2017, n.27, pp.11-22. ISSN 1851-7587.

The NMDA receptor is the major subtype of glutamate receptors involved in physiological processes such as neuronal development, synaptic plasticity, learning and memory and numerous pathological conditions such as ischemic damage, chronic pain, psychosis, and other neurodegenerative disorders. It has been suggested regulation by phosphorylation as a mechanism altering the relative permeability of the NMDAR to Ca2 + during ischemia. This paper presents a series of peptides that were designed based on GluN2B subunit interactions with proteins DAPK1, SRC and D2R related to the effects generated after an ischemic event. The identification of binding sites among these molecules and GluN2B allowed to make an in silico design of peptides that can eventually block these interactions and reduce the harmful effects of diseases such as ischemia. Our results demonstrate that the rational design of peptides is a good strategy to generate new therapeutic agents.

Keywords : NMDA; Ischemia; Design; Peptides; In silico.

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