Resumen

GRENON, S., et al. Prevalence and antimicrobial profile of Shigella causing acute diarrheal disease in pediatrics in Posadas, Misiones. Rev. cienc. tecnol. [online]. 2022, n.38, pp.81-90. ISSN 1851-7587.  http://dx.doi.org/10.36995/j.recyt.2022.38.009.

Our objective was to evaluate the presence and microbiological characteristics of Shigella in children with acute diarrhoeal disease (ADD), attended at the Paediatric Hospital of Posadas, Misiones between 2016 and 2019. All ADEs documented in the laboratory were included. Standardised microbiological techniques were used. We considered age groups: infants (L)≤ 2 years, preschool (PE): 3-5 years, school (E): 5- 14 years. We recorded 106/2128 (5%) Shigella spp. isolates, with a higher frequency in summer (54.5%). S. flexneri (64; 60.4% serotypes 02(54), 03(3), AA479(2) and 01(1)) and S. sonnei (37; 34.9%) predominated. Mean age: 4.2 years (1.2 m-11a). Those < 5 years old were the most affected (70 %). Hospitalisation was required in 7.7%. S. flexneri/S. sonnei were: in L (42.9% vs 27.7%) and in E (27 vs 42.9%). Overall resistance to AMP was 72.7% and 58.1% to TMS. 97% were sensitive to furazolidone (FUR), cefpodoxime and fluorinated quinolones. In S. flexneri the % resistance to AMP/TMS was (78.7/44.8) and in S. sonnei (61.8/80.6) p< 0.05). We detected 6 resistance phenotypes with low multi-resistance (2.6%). FUR remains an empirical therapeutic option in outpatients.

Palabras clave : Acute diarrhoeal disease; Shigella; Children; Prevalence; Antimicrobial resistance.

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