Abstract

CASTAGNINO, Jorge Pedro; MUSELLA, Rosa María  and  PALMERO, Domingo. DRESS syndrome induced by anti-tuberculosis drugs. Rev. amer. med. respiratoria [online]. 2011, vol.11, n.3, pp.141-146. ISSN 1852-236X.

We present four patients with pulmonary tuberculosis and severe adverse reactions to antituberculosis drugs. These patients had skin rash, hepatitis, eosinophilia, fever, and one of them had renal failure; all these signs conform the diagnosis of DRESS syndrome. This syndrome is caused by a severe hypersensitivity reaction to different drugs. It is usually caused by anticonvulsants, sulfonamides, some antiviral drugs, among others drugs. Anti-tuberculosis drugs can also cause this potentially fatal syndrome. The importance of surveillance for early detection and treatment of adverse drug reactions is emphasized.

Keywords : Adverse drug reactions; DRESS; Eosinophilia; Tuberculosis.

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