SciELO - Scientific Electronic Library Online

vol.13 issue4Reporte de caso: fístula traqueoesofágica e insuficiencia respiratoria tardía post stent metálico autoexpandible en esófago. Tratamiento con stent traqueal de Dumon author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista americana de medicina respiratoria

On-line version ISSN 1852-236X


TALAVERA, María L et al. Hipertensión pulmonar grave reversible asociada al uso de dasatinib en un paciente con leucemia mieloide crónica. Rev. amer. med. respiratoria [online]. 2013, vol.13, n.4, pp.239-242. ISSN 1852-236X.

Pulmonary arterial hypertension is a rare disease that is characterized by a progressive increase in vascular pulmonary resistance, chronic right ventricle failure and premature death. Pulmonary arterial hypertension can be either idiopathic or associated to other conditions such as portal hypertension, human immunodeficiency virus, connective tissue diseases, congenital systemic-to-pulmonary shunts or associated to different drugs/toxins. Encouraging progress has been made by targeting the main vasoproliferative aspects of the disease. Tyrosine kinase inhibitors (TKI) are promising emerging therapeutics. Imatinib, a selective TKI approved for the treatment of chronic myeloid leukaemia, has demonstrated some efficacy in treating pulmonary arterial hypertension in a phase II study. However, the TKI dasatinib, also approved for therapy of chronic myeloid leukaemia, has been linked to reversible pulmonary arterial hypertension and right ventricular failure, with pleural effusion, suggesting the possibility of drug-related pulmonary arterial hypertension.

Keywords : Pulmonary arterial hypertension; Reversible; Drug toxicity; Dasatinib.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License