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Revista americana de medicina respiratoria
On-line version ISSN 1852-236X
Abstract
ERNST, Glenda et al. Citoquinas inflamatorias del lavado broncoalveolar en pacientes con enfermedades pulmonares intersticiales difusas: Utilidad en estudios de investigación. Rev. am. med. respir. [online]. 2014, vol.14, n.3, pp.221-231. ISSN 1852-236X.
Interstitial Lung Diseases (ILD) are characterized by inflammation and fibrosis. The role of bronchoalveolar lavage (BAL) in the diagnosis of ILD, has been recently revalued. The aim of this work was to evaluate BAL´s inflammatory cytokines associated with ILD. We collected BAL from 28 patients with ILD and15 control subjects with healthy lungs. We counted the whole BAL cell number and determined cytokines levels by ELISA. We found a significant increase in the whole BAL cell count and IL-6 levels in patients with fibrotic non-specific interstitial pneumonia (NSPI), hypersensitivity pneumonitis (HP) and sarcoidosis in comparison with the control group. We also observed a significant increase of IL-8 in BAL from usual interstitial pneumonia/idiopathic pulmonary fibrosis (UIP/IPF) in comparison with the control group. We didn´t find relationship between cytokines levels and lung function parameters. BAL could play an important role to understand the inflammatory process associated with ILD. When BAL is used together with complete clinical information, BAL cell differential count and inflammatory patterns could contribute to the diagnostic evaluation. BAL processing and analysis of this fluid are critically important for providing useful information. In this study we evaluated the use of BAL as a research tool to understand inflammatory patterns associated with ILD.
Keywords : Interstitial Lung Diseases; Bronchoalveolar Lavage; Lung Inflammation.