Abstract

GOMEZ TEJADA, Ricardo Adrián et al. Bronquiectasias no relacionadas a fibrosis quística en un hospital universitario: Relación entre compromiso funcional y extensión anatómica. Rev. am. med. respir. [online]. 2014, vol.14, n.4, pp.365-374. ISSN 1852-236X.

Introduction: Bronchiectasis is a permanent abnormal dilatation of an airway and the diagnosis should be made by computed tomography (HRCT). Objectives: a) to compare the HRCT anatomical involvement with standard spirometric parameters, b) to assess recorded exacerbations with regard to treatment received, c) to describe the microbiological findings. Methods: Clinical records of 33 stable outpatients with non cystic fibrosis bronchiectasis were retrospectively studied. Exacerbations were recorded during the year prior to the first visit. HRCT with quantification of affected lobes, spirometry and sputum culture were performed to all patients. Results: A) There were no significant differences in lobar extension for FEV1 (milliliters) (p ≤ 0.180), FEV1% predicted (p ≤ 0.102); FEV1/FVC ratio (p ≤ 0.680). The differences were significant for FVC % predicted (p ≤ 0.037). B) Exacerbations (≤ 1, n = 5; ≥ 2, n = 28) were frequent events. There were 24/33 patients treated with inhaled corticosteroids; 9/33 with systemic corticosteroids and 29/33 with antibiotics. C) Bacteriological isolations were reported in 11/33 patients: 6 for P. Aeruginosa, 2 S. Pneumoniae, 2 S. aureus, 1 S. viridans. Relative frequencies showed no influence of treatment with inhaled corticosteroids (0.558), systemic corticosteroids (0.668) and antibiotics (0412) regarding exacerbations. Conclusions: Evaluation of FVC% predicted can be a simple resource to assess the anatomic involvement in non-cystic fibrosis bronchiectasis. The effects of conventional therapy on the prevalence of clinical exacerbations could not be demonstrated with this study design.

Keywords : Bronchiectasis; High resolution computed tomography of the lungs; Respiratory function tests.

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