Abstract

VASQUEZ, Julia et al. Resultados tempranos y alejados del trasplante pulmonar en el enfisema avanzado. Rev. am. med. respir. [online]. 2015, vol.15, n.4, pp.283-291. ISSN 1852-236X.

Introduction and objectives: Emphysema is the most frequent indication of lung transplantation (LT)). The aim of this paper is to evaluate the demographic and functional characteristics of patients with emphysema and to analize survival. Methods: Observational and analytic study of 84 patients with emphysema who were transplanted between june 1994 and march 2012. Kaplan-Meier method was used to analyze survival. Results: 84 (40%) out of 212 transplanted patients had diagnosis of emphysema; 11 (13%) of them with diagnosis of alfa-1 antitrypsin defcit. Seventy of them (83%) were single lung transplantation and 14 (17%) double lung transplantation; 69 in elective situation (82%) and 15 in emergency/urgency situation (18%). Mean age: 54, 95 ± 6, 10 years, 54 male (64%). Baseline characteristics were: forced expiratory volume in first second (FEV₁) 0,60 ± 0,28 L (20 ±9%); forced vital capacity (FVC) 1,78 ± 0,62 L (46 ± 16%); mean pulmonary artery pressure (map) 21,08 ± 5,79 mmHg; mean partial artery oxygen pressure (PaO₂) 67,54 ± 12,27 mmHg; mean partial carbon dioxide pressure (PaCO₂) 46,40 ± 8,04 mmHg, Six minute walk test (6MWT) distance was 225,59± 113,67 m. In-hospital mortality was 16% (13/84). Global survival at 1, 3, 5, 7 y 10 years was 67%, 53%, 40%, 27% y 13% respectively. Conditional survival at 3, 5, 7 y 10 years was 79%, 59%, 41% y 20% respectively. Conclusions: lung transplantation is a therapeutic option in advanced emphysema. This paper shows characteristics and survival of COPD patients who underwent lung transplantation in the University Hospital Foundation Favaloro.

Keywords : Lung transplantation; Emphysema; COPD.

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