SciELO - Scientific Electronic Library Online

vol.1 número1 índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados



  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO


Insuficiencia cardíaca

versión On-line ISSN 1852-3862


ECHAZARRETA, Diego et al. Administración crónica de sildenafil en la hipertensión pulmonar. Insuf. card. [online]. 2006, vol.1, n.1, pp. 23-27. ISSN 1852-3862.

Introduction and objectives- Pulmonary hypertension is a common illness in patients waiting for a heart or lung transplantation. However, its treatment has been reduced, only to the calcium antagonists, oral anticoagulation and prostaglandins. Recently, sildenafil has been used for improvement the hemodynamic state of this group, taken account the vasodilatation capacity of the pulmonary bed. Patients and methods- Observational study of 40 patients (33 women and 7 men, mean age) with previous diagnostic of pulmonary hypertension and functional capacity (New York Heart Association classification) II-III. Two groups: Group A with means of sildenafil 103.75 mg/day and Group B with controls. Baseline, six-month follow-up were based on functional capacity (six minutes walk test) and right ventricular catheterization. Results- We found a significant decrease of the pulmonary arterial pressure (69±3 a 49±3 mm Hg, t=21 p: 0,000) and the pulmonary vascular resistance (1866±11 a 948±7 dinas.s-1/cm-5 t=3.24 p: 0, 0002). The Group A improves the Six Minute Walk Test in a significant statistic way (156±9 a 203±7 metros t=- 22,798 p: 0,000). No significant adverse effects of sildenafil were detected. Conclusions- Using sildenafil mean 103.75 mg per day, our patients, improve hemodynamic profile and functional capacity.

Palabras clave : Sildenafil; Pulmonary hypertensionn; Heart failure; transplant.

        · resumen en Español     · texto en Español     · Español ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License