Abstract

ALONSO, Enrique  and  ALONSO, Enrique. What is the role of neurohormonal system in heart failure with preserved ejection fraction?. Insuf. card. [online]. 2010, vol.5, n.1, pp.03-10. ISSN 1852-3862.

The role of neurohormonal system (NHS) in the pathophysiology of systolic heart failure (SHF) is transcendental. However, their participation in heart failure with preserved ejection fraction (HFpEF) is not fully clear, since the data is provided from observational studies in patients with SHF. Small studies have shown that the degree of activation of SNH in the HFpEF is lower than in the SHF. Experimental models of hypertensive heart disease showed the active involvement of NHS in the progression of cardiac hypertrophy to SHF. Increased blood levels of pro-BNP and BNP reflect structural and hemodynamic alterations in patients with HFpEF that facilitate early identification of subclinical abnormalities. The PROBE-HF study showed that type II diabetic or hypertensive patients with blood dosages of pro-BNP > 125pg/ ml identify a particular group of patients which leads us to request routine tests to acquire functional and structural information about ventricular dysfunction, in order to indicate prematurely the appropriate therapeutic measures.

Keywords : Heart failure with preserved ejection fraction; Sympathetic nervous system; Neurohormonal system; Renin-angiotensin-aldosterone system; Natriuretic peptide.

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