Abstract

LOBO MARQUEZ, Lilia Luz. The "Continuum" of heart failure. Insuf. card. [online]. 2010, vol.5, n.1, pp.25-31. ISSN 1852-3862.

The different phenotypes of heart failure are not only the result of the interplay neurohormonal, hemodynamics and inflammation, but chronic or acute activation of these systems on substrates ventricular defined (purely failures or purely systolic diastolic) determine a particular type of clinical and pathophysiological presentation. In addition, external factors modifiable and not modifiable could determine a particular phenotype. Circumstances or contingencies are those of the environment, pathological processes, adaptive ability or disability, reactive processes, the presence of toxic factors, risk factors uncontrolled exacerbation, among others. Each type of heart failure is the result of a combination of factors ranging from a certain genotype to phenotype, influenced by these new circumstances that may be modulating this scenario. Advances in physiopathology have no doubt, a great therapeutic impact.

Keywords : Heart failure; Genotype; Phenotype; Hemodynamics; Neurohormonal; Inflammation.

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