Abstract

D'ORTENCIO¹, Alfredo  and  NAVIGANTE², Alfredo. Mitochondrial dysfunction and cardiovascular disease. Insuf. card. [online]. 2016, vol.11, n.4, pp.201-214. ISSN 1852-3862.

Mitochondria are cellular organelles in charge of providing the greater part of the energy required for cellular activity (cellular respiration), acting as power stations of the cell by synthesizing adenosine triphosphate (ATP) at the expense of metabolic fuels. These mobile organelles exist in dynamic networks. They continuously join by the process of fusion and divide by the process of fission. These events are involved in a wide variety of biological processes, including embryonic development, metabolism, apoptosis and mitophagy. Mitochondrial dysfunction is considered esa common pathway in a number of diseases, both acute and chronic, by the phenomenon of oxidative stress and the generation of systemic inflammatory response. This dysfunction is involved in the pathogenesis of different diseases and genetic conditions such as neurodegenerative, neoplastic, endocrine and cardiovascular diseases, among others. The development of effective metabolic and pharmacological treatments for defined mitochondrial diseases holds promise for future therapies that could improve the symptoms of a broad range of metabolic and degenerative disorders, and even aging. This update revises how altered mitochondrial dynamics in several heart diseases and how this knowledge could provide new therapeutic targets for treatment.

Keywords : Mitochondria; Mitochondrial dynamics; Mitochondrial dysfunction; Inflammation; Pulmonary hypertension; Ductus arteriosus; Diabetes; Heart failure; Cancer.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )