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Acta Odontológica Latinoamericana
On-line version ISSN 1852-4834
Abstract
CANZOBRE, Mariela C; PAGANELLI, Alejandra R and RIOS, Hugo. Effect of periapical inflammation on calcium binding proteins and ERK in the trigeminal nucleus. Acta odontol. latinoam. [online]. 2019, vol.32, n.2, pp.103-110. ISSN 1852-4834.
Peripheral inflammation induces plastic changes in neurons and glia which are regulated by free calcium and calcium binding proteins (CaBP). One of the mechanisms associated with the regulation of intracellular calcium is linked to ERK (Extracellular Signal-Regulated Kinase) and its phosphorylated condition (pERK). ERK phosphorylation is important for intracellular signal transduction and participates in regulating neuroplasticity and inflammatory responses. The aim of this study is to analyse the expression of two CaBPs and pERK in astrocytes and neurons in rat trigeminal subnucleus caudalis (Vc) after experimental periapical inflammation on the left mandibular first molar. At seven days post-treatment, the periapical inflammatory stimulus induces an increase in pERK expression both in S100b positive astrocytes and Calbindin D28k positive neurons, in the ipsilateral Vc with respect to the contralateral side and control group. pERK was observed coexpressing with S100b in astrocytes and in fusiform Calbindin D28k neurons in lamina I. These results could indicate that neural plasticity and pain sensitization could be maintained by ERK activation in projection neurons at 7 days after the periapical inflammation.
Keywords : Neuroplasticity; pERK kinase; S100b protein; Calbindin D28k; Apical periodontitis; Trigeminal nucleus.