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BAG. Journal of basic and applied genetics

On-line version ISSN 1852-6233


ANDRIOLI, Nancy B  and  MUDRY, Marta D. Cytological and cytogenic effects induced by thiabendazole on Allium cepa root meristem. BAG, J. basic appl. genet. [online]. 2011, vol.22, n.2, pp.17-23. ISSN 1852-6233.

The toxicity and genotoxicity of thiabendazole (TBZ) in its commercial formulation Foldan® was studied in Allium cepa meristematic cells at concentrations ranging between 10 and 250 µg / ml. Our results show that exposure to TBZ induces a significant increase in the frequency of anaphase telophase chromosomal aberrations, micronuclei and binucleated cells at all the concentrations of TBZ assayed. The frequency of anaphase telophase aberrations was observed to reach a plateau at the concentration of 50 µg / ml of TBZ, which could be probably due to TBZ mitotic toxicity manifested at concentrations of 100 and 250 µg / ml. An increase was also observed in the rate of metaphase and anaphase, which was, in turn, indicative of alterations in chromatid segregation. Results from the present study indicate that exposure to TBZ induces toxicity and genotoxicity, both being consistent with mechanisms that interfere with microtubule formation.

Keywords : Genotoxicity; Cytotoxicity; Mitotic index; Micronuclei; Binucleates; Thiabendazole.

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