Resumen

TORRESANI, ME et al. Do thyrotropin values influence on the decrease of body weight in adult women with overweight and obesity?. Diaeta [online]. 2014, vol.32, n.149, pp.07-13. ISSN 1852-7337.

Introduction: The increase in serum thyrotropin (TSH), even within the reference range, may be a predictor of the difficulty found while reducing body weight in adult women. Objective: To study whether TSH values influence on the decrease of body weight in adult women with overweight and obesity. Methodology: Design controlled intervention on non-random sample of women> 30 years old and BMI ≥25 kg/m², who attended an Endocrine Center of the Autonomous City of Buenos Aires. Dependent variable: change in body weight between initial consultation and control (<1% ≥1% per week); Independent variables: TSH (in mIU / L and categorized in Group A; ≥ 2.5 mIU/L and Group B: <2.5 mIU/L), age (<40, 40- 65 and> 65 years old), Grade of overweight (BMI: 25.0-29.9, 30-34.9 and ≥35 kg/m²), degree of adherence to treatment (expressed in % compliance for the food plan and scheduled and categorized physical activity in ≤ 50% 60- 70% and> 70 %) and time between initial visit and control (2, 3 or 4 weeks). SPSS 15.0 establishing measures of central tendency, Odds ratio with confidence intervals (95% CI), X², Fisher's test and Pearson correlation with p value <0.05. Results: 105 women (50.8±12.2 years old) were studied with a middle BMI of 30.0±4.9 kg/m². 57.1% were hypothyroid treated with LT4. According to value of TSH: Group A (27.6%) ≥ 2.5 mIU/L and Group B (72.4%) <2.5 mIU/L. As from the intervention program, most reduced less than 1% per week with respect to their initial weight (51.7% of group A and group B 56.6%), with a degree of adherence to treatment between 60 and 70% (51.7% group A and Group B 50.1%) without significant differences between groups. No association between weekly weight loss with thyroid function was found (OR: 0.64; CI: 0.29-1.39; p: 0.32) nor with TSH (OR: 1.21; CI: 0.51-2.86; p: 0.66). Direct correlation between weekly weight loss and the degree of adhesion to treatment was found (r: 0.464; p: 0.000), and an inverse one between the time elapsed until the first control (r = -0.30, p = 0.002), and BMI ranges, (r = -0.282; p 0.004), regardless of age, the thyroid function or the TSH value present in the patients. Conclusions: The TSH levels and the thyroid function did not influence on the weekly weight loss. The decrease in weight was associated with a direct adherence to treatment regardless of age, thyroid function or value of TSH.

Palabras clave : Weekly weight loss; Overweight or obesity; Hypothyroidism; TSH value; Adult women.

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