Resumen

BERENSTEIN, Mario; TACUS, Leonardo; KOBRINSKY, Pablo  y  VAINERAS, Daniel. Registro de acido hialuronico intrarticular en el tratamiento de la artrosis de rodilla, en la Argentina. Rev. Asoc. Argent. Ortop. Traumatol. [online]. 2019, vol.84, n.2, pp.122-128. ISSN 1852-7434.

Background: Treatment of knee osteoarthritis with intra-articular hyaluronic acid (IA-HA) is frequently used in Argentina, with different dosing forms and injection regimens. Our main objective was to provide real world data on the use and effectiveness of IA-HA. Methods: In this observational retrospective cohort study we studied 1227 patients with knee osteoarthritis treated with IA-HA 20 mg/2 ml weekly (76%-20 mg group) and 40 mg/2 ml (24%-40 mg group) according to standard practice. Follow-up was 6 months and effectiveness was assessed by the 5-point Likert scale and a response of 50% or more. Results: Median number of injections was 5 (20 mg) and 3 (40 mg). Both groups had a significant improvement in the Likert scale from baseline to 6 months. Median score improved from 4 (mean 3.77 ± 0.69) at baseline to a median of 2 (mean 1.99 ± 0.76) at 6 months (20 mg group, p<0.001) and from a median of 4 (mean 3.65 ± 0.65) to a median of 2 (mean 1.86 ± 0.72) in the 40 mg group, p<0.001. The percentages of patients with a response of 50% or more at 6 months were 61% and 66%, respectively. In the multivariate analysis, the 50% response rate was associated with a higher baseline score, younger age and shorter duration of disease. Only one patient in the 20 mg group (0.1%) experienced a serious treatment-related adverse event (septic arthritis) following injection. Conclusion: Our study carried out during routine clinical practice supports the effectiveness of IA-HA for the management of knee osteoarthritis with a clinical advantage observed at a 6-month follow-up.

Palabras clave : Intra-articular; Hyaluronic acid; Knee; Arthrosis; Osteoarthritis.

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