Resumen

GUBERT, Marcelo Joaquín et al. Multislice Quantitative Computed Tomography allozos early detectíon of bone mineral density alterations induced by atherogenic diet in a growing rat experimental model. Rev. argent. radiol. [online]. 2012, vol.76, n.1, pp.43-50. ISSN 1852-9992.

Purpose. To demónstrate the utility of Multislice Quantitative Computed Tomography (MS-QCT) in the early detection of mandibular bone mineral density (BMD) alterations induced by an atherogenic diet in a growing rat experimental model. Materials and Methods. Male weanling Wistar rats (n =16) were divided by body weight (Wt) into 2 groups: control (C) and experimental (E), with no significant differences in the mean initial Wt (p>0.05). C was fed rodent stock diet ad libitum, and E an atherogenic diet for 3 weeks (3w). Zoometry (body weight and length) and diet intake (g/lOOg rat/day) were monitored. At 3 w in serum (mg/dL) lipid-lipoprotein profile was studied: total cholesterol (t-C), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), non-HDL cholesterol (non-HDL-C) and MS-QCT (Philips 64 CT, quantified with the eFilm Workstation 2.1) in seven mandibular áreas (MA): n°lto 4: from chin to mandibular foramen, n° 5: coronoid process, n° 6: condylar process, n° 7: angular process. Statistics: Pearson's correlation between BMD in each MA and serum t-C. p<0.05 was considered significant. Results. (mean ± SD) At 3w, neither zoometric ñor intake differences were observed (p>0.05). Correlation coefficients (r) and their significance levéis (p) were relevant in 5/7 MA. MA1-.-0.580 (p=0.019), MA2:-0.709 (p=0.002), MA3:-0.635 (p=0.008), MA5:-0.674 (p=0.004), MA6:-0.564 (p=0.023). Conclusions. These results suggest that MS-QCT is an imaging diagnostic method that allows the early detection of mandible bone architecture alterations induced by an atherogenic diet. Inverse correlation between BMD and t-C would indícate an association between an atherogenic diet intake and potential temporomandibular disorders.

Palabras clave : Atherogenic diet; Bone architecture; Quantitative computed tomography; Rat mandible.

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