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Revista argentina de radiología

On-line version ISSN 1852-9992

Abstract

BERGERO, Miguel A. et al. Correlation between PSA kinetics and positivity of f18-PSMA positron emission tomography in the relapsed prostate cancer. Rev. argent. radiol. [online]. 2022, vol.86, n.3, pp.158-165.  Epub Oct 05, 2022. ISSN 1852-9992.  http://dx.doi.org/10.24875/rar.m22000021.

Introduction:

Prostate-specific antigen (PSA) kinetics (PSA velocity [PSAV] and PSA doubling time [PSADT]) are predictors of positivity in Choline PET/CT, but this correlation has not been correctly established in PSMA PET/CT.

Objective:

To evaluate the diagnostic correlation between PSA kinetics and positivity of 18F PSMA PET/CT in patients with relapsed prostate cancer (RPC).

Material and methods:

We performed an observational cross-sectional study of 54 patients with RPC that were evaluated with 18F-PSMA PET/CT. The concordance between 18F-PSMA PET/CT and PSA kinetics was analyzed.

Results:

The mean age was 68 ± 8 years. Time to relapse had a median (Q1-Q3) of 29 (8; 48) months. The trigger PSA showed a median of 3.14 (0.73-8.69) ng/dl. 18F-PSMA PET/CT showed a positivity of 80%. The ROC curves showed an AUC of 0.93 for PSAV (95%CI0.83-1; p = 0.0001). A cut-off points of 0.85 ng/ml/year showed a sensitivity of 88% and a specificity of 87%. 97% of the 18F-PSMA PET/CT were positive with a PSAV > 0.85 ng/ml/year (p = 0.0001). While the ROC curves showed an AUC of 0.38 for PSADT (95%CI 0.21- 0.57; p = 0.321) without showing diagnostic value.

Conclusion:

PSAV was a predictor of positivity in 18F-PSMA PET/CT in patients with RPC, but PSADT was not.

Keywords : Prostate cancer; Positron-emission tomography; PSMA.

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