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Revista de la Facultad de Ciencias Agrarias. Universidad Nacional de Cuyo

On-line version ISSN 1853-8665

Abstract

GONZALEZ, Roxana Elizabeth; SOTO, Verónica Carolina; SANCE, María Mirta  and  GALMARINI, Claudio Rómulo. Garlic (Allium sativum L.) inhibitory effect on platelet activity induced by different agonists. Rev. Fac. Cienc. Agrar., Univ. Nac. Cuyo [online]. 2021, vol.53, n.1, pp.46-54. ISSN 1853-8665.

Platelets are essential elements of human blood. In addition to their normal role, platelets are involved in causing myocardial infarction, stroke and other thrombotic disorders. Platelet activation in vivo, probably involves a combination of agonists. Garlic has beneficial effects due to its ability to inhibit platelet aggregation and thromboxane formation. The aim of this work was to evaluate the ability of garlic extracts to inhibit platelet aggregation induced by different agonists and their mixtures in different donors. Significant differences were found in platelet aggregation in response to each agonist (P ≤ 0.05). The highest antiaggregatory effect was observed with arachidonic acid and the lowest effect with collagen-arachidonic acid mixture. Interaction effects between donor and agonist (or mixtures) were detected. The study showed the potential of aqueous garlic extracts to prevent platelet aggregation induced by different agonist.

Keywords : Allium sativum L.; Perla INTA cultivar; Coagulation; Antiaggregatory effect.

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