Abstract

MARTINEZ, Jonatan et al. Acute renal failure associated with colistin treatment in the intensive care unit. Rev. nefrol. dial. transpl. [online]. 2014, vol.34, n.3, pp.108-111. ISSN 2346-8548.

Background: The association of colistin and acute kidney injury has shown different results in several studies since the reintroduction of this drug in the common practice. Methods: A prospective and observational study of patients that received treatment with colistin for at least 48 hours in the Intensive Care Unit (ICU) was performed. Results: 104 patients participated in the study, of which 47 % (49) developed acute kidney injury associated to colistin (AKI-C). These patients were grouped according to the RIFLE classification: patients with Risk (10); patients with Injury (13); patients with kidney Failure (26). 6 patients required hemodialysis. The Charlson'Ts score and the presence of shock were associated to the development of AKI-C. Neither age, APACHE, basal serum creatinine nor accumulated doses of colestin were associated to the development of AKI-C. The AKI-C was associated to a greater in-hospital mortality (p=0.003). Conclusion: The AKI-C is a frequent condition and its associated to a greater in-hospital mortality. The implementation of nephroprotection strategies in patients that receive colestin and the development of new antibiotics with less toxicity could improve the evolution of these patients.

Keywords : Acute kidney injury; Colistin; Intensive care unit.

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