Abstract

SCUBLINSKY, D. Update on the use of medicinal cannabinoids in rheumatic diseases. Rev. argent. reumatolg. [online]. 2020, vol.31, n.4, pp.25-29. ISSN 0327-4411.

Medical marijuana has been proposed in recent years as a solution to some medical problems refractory to other treatments. Chronic pain is a common symptom among patients who consult a rheumatologist. Different diseases can be involved in this pan-syndrome that ranges from autoimmune diseases, locoregional pain syndromes, degenerative diseases to disorders with psychological components. In many of these cases, especially the last two, pharmacological interventions are not always effective or safe in the short, medium or long term. In this review, the most current literature on the subject regarding cannabinoids and the treatment of rheumatic diseases will be analyzed. Despite the focus of the issue in recent years and the recent regulation of the Medical Cannabis Law for its self-cultivation and sale in pharmacies in Argentina, there is still insufficient data for the use of cannabinoids in the short, medium and long-term in rheumatic diseases. In recent years, some physiological studies have appeared about the potential immunomodulatory effect of cannabinoids in rheumatoid arthritis and systemic sclerosis (SS), and some clinical studies in SS, but there is still a long way to go to travel in this direction. In this review, the current literature on cannabinoids in the treatment of rheumatic diseases will be analyzed and this evidence will be discussed in relation to the local regulatory context.

Keywords : Cannabis; cannabinoids; Arthritis; Fibromyalgia; Systemic Sclerosis.

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