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Revista argentina de reumatología

versión impresa ISSN 0327-4411versión On-line ISSN 2362-3675


PAPASIDERO, Silvia Beatriz et al. Delayed onset of biologic or targeted synthetic dmards in rheumatoid arthritis patients and associated factors. Rev. argent. reumatolg. [online]. 2022, vol.33, n.1, pp.5-13. ISSN 0327-4411.


the goal of rheumatoid arthritis (RA) treatment is to obtain remission or low activity of the disease. In those patients who did not achieve this objective with conventional treatment, biologic or targeted synthetic disease-modifying antirheumatic drugs (bDMARD or tsDMARD, respectively) are indicated. The period of time between the prescription of these medications and its administration is variable.


to describe the delay time between the prescription of a bDMARD or tsDMARD and the administration of the first dose, and its related reasons.

Materials and methods:

observational, analytical, retrospective study. Medical records of patients with a diagnosis of RA who were prescribed a bDMARD or tsDMARD were reviewed. Sociodemographic data and characteristics of the disease were recorded. Regarding the indication of bDMARDs or tsDMARs, the following data was collected: prescription date, date on which the patient received the first effective dose and reason for the delay.


102 patients were included. The median delay time from the drug prescription until the patient received the first dose was 240 days (IQR 113-504). The main reason for delay was of bureaucratic nature (47%). Patients with low disease activity obtained the medication with a shorter delay (113 days) compared to those with moderate activity (242 days) and high activity (332 days); p=0.01. Patients with a delay related to bureaucratic causes, presented a lower level of education (60% vs 17% with higher education) and residence in the Province of Buenos Aires (58% vs 31% with residence in Autonomous City of Buenos Aires), and these differences were statistically significant.


the median delay time to onset of bDMARDs or tsDMARDs was approximately 8 months. The main reason for this delay was of bureaucratic nature, being more frequent in those with lower educational level and residence in the Province of Buenos Aires.

Palabras clave : rheumatoid arthritis; treatment; access.

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